PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia
Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D (PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human NATURAL DEODORANT ciliopathy Joubert Syndrome (JBTS22) and retinal degeneration in mice.In this study, we purified the prenylated cargo of PDE6D by affinity proteomics to gain